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Amoxil (amoxicillin) is an antibiotic of the penicillin group. Amoxil is applied in treatment of bacterial infections strongly suspected to be caused by susceptible strains of microorganisms, including infection of respiratory tract, urinary tract infections, ear infections, bladder infections, salmonella infection, pneumonia, or gonorrhea.
Amoxil is also indicated with clarithromycin in treatment of stomach ulcers proved to be caused by Helicobacter pylori infection.
Amoxil works by inhibiting the formation of cell wall in Gram-positive and Gram-negative bacteria.
Amoxicillin trihydrate is supplied in the form of capsules, chewable tablets, and pediatric suspension for oral administration, as well as of the solution for intravenous injections. Amoxil is better absorbed, comparing to other antibiotics of this class.
Amoxil is used to treat infections due to organisms that are susceptible to the effects of amoxicillin. Common infections that amoxicillin is used for include infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis), lungs (pneumonia), urinary tract, and skin. It also is used to treat gonorrhea.
For most infections in adults the dosing regimens for amoxil are 250 mg every 8 hours, 500 mg every 8 hours, 500 mg every 12 hours or 875 mg every 12 hours, depending on the type and severity of infection.
For the treatment of adults with gonorrhea the dose is 3 g given as one dose.
For most infections, children older than 3 months but less than 40 kg are treated with 25 mg/kg/day in divided doses every 12 hours, 20 mg/kg/day in divided doses every 8 hours, 40 mg/kg/day in divided doses every 8 hours or 45 mg/kg/day in divided doses every 12 hours depending on type and severity of the infection.
Drug Class and Mechanism
Amoxil is an antibiotic that belongs to a class of antibiotics called penicillins.
These antibiotics all have a similar mechanism of action. They do not kill bacteria, but they stop bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall.
Amoxil is effective against many different bacteria including H. influenzae, N. gonorrhoea, E. coli, Pneumococci, Streptococci, and certain strains of Staphylococci.
If you miss a dose of Amoxil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Store Amoxil capsules as well as 125 and 250 mg dry powder at or below 20 degrees C (68 degrees F); tablets, chewable tablets, as well as 200 and 400 mg dry powder at or below 25 degrees C(77 degrees F).
Nausea, vomiting or diarrhea may occur. If any of these effects persist or worsen, notify the doctor or pharmacist promptly.
This medicine may cause temporary staining of the teeth. Proper brushing will usually remove any staining and may prevent it from occurring.
Tell the doctor immediately if any of these highly unlikely but very serious side effects occur:
- dark urine,
- persistent nausea or vomiting,
- stomach/abdominal pain,
- yellowing eyes or skin,
- easy bruising or bleeding,
- persistent sore throat or fever.
This medication may rarely cause a severe intestinal condition (pseudomembranous colitis) due to a resistant bacteria. This condition may occur weeks after treatment has stopped.
When used in combination with Metronidazole possible:
- pain in epigastric area,
- in individual cases,
- interstitial nephritis,
- pseudomembranous colitis,
- disorders of hematopoiesis.